| Organ | Manifestation |
| Ear, nose throat | Nasal crusting, sinusitis, otitis media, persistent rhinorrhea, purulent/bloody nasal discharge, oral/nasal ulcers, bony and cartilage destruction (e.g. saddle nose deformity) |
| Lung | Cough, dyspnea, stridor, hemoptysis, pleuritic pain, tracheal or subglottic stenosis, pulmonary fibrosis, pulmonary arterial hypertension, parenchymal lung nodules |
| Kidney | Acute renal failure, pauci-immune crescentic necrotizing glomerulonephritis, interstitial nephritis |
| Skin | Leukocytoclastic angiitis, purpura, ulceration, urticaria, livida reticularis, nodules |
| Eye | Conjunctivitis, corneal ulceration, epislceritis/scleritis, optic neuropathy, retinal vasculitis, uveitis, diplopia, proptosis |
| Nervous system | Mononeuritis multiplex, cranial nerve abnormalities, central nervous system lesions |